Alcohol 
Alcohol 
UNSAFE 
It is unsafe to consume alcohol with Linatab 5. 
Pregnancy 
Pregnancy 
SAFE IF PRESCRIBED 
Linatab 5 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. 
Breastfeeding 
Breastfeeding 
SAFE IF PRESCRIBED 
Linatab 5 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. 
Driving 
Driving 
CAUTION 
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur. 
Kidney 
Kidney 
SAFE IF PRESCRIBED 
Linatab 5 is safe to use in patients with kidney disease. No dose adjustment of Linatab 5 is recommended. 
Liver 
Liver 
SAFE IF PRESCRIBED 
Linatab 5 is safe to use in patients with liver disease. No dose adjustment of Linatab 5 is recommended. 
description 
Medical Overview 
Introduction 
Linatab 5 is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels. This helps to prevent serious complications of diabetes like kidney damage and blindness. Linatab 5 is normally prescribed when diet and exercise alone or other medicines do not prove sufficient to control your blood sugar level. Your doctor may prescribe it alone or along with other diabetes medicines. It can be taken with or without food. The dose will depend on your condition, and blood sugar levels. Therefore, you should use it as advised by your doctor. You should take it regularly at the same time each day to get the most benefit, and you should not stop unless your doctor recommends. This medicine is helping you to control your blood sugar levels and prevent serious complications in the future. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes. The most common side effect of taking this medicine is headache. This is usually minor and improves with time. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulphonylurea, so you need to know how to recognize and deal with it. It may also cause upper respiratory tract infections like sore throat, cough, and cold. Contact your doctor if the side effects worry you or if they do not go away. Before taking this medicine, let your doctor know if you have ever had kidney disease, heart or pancreas problems, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines you are taking may interfere with this medicine's working. So, make sure your doctor knows about all the other medicines you are using. Limit your alcohol intake while taking this medicine because it can increase your risk of developing low blood sugar levels. You may need regular tests such as kidney function and blood glucose levels to check that the medicine is working properly. 
Uses of Linatab 5 
Type 2 diabetes mellitus 
Side effects of Linatab 5 
Common 
Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea 
Headache 
Nasopharyngitis (inflammation of the throat and nasal passages) 
Cough 
Allergic reaction 
How to use Linatab 5 
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Linatab 5 may be taken with or without food, but it is better to take it at a fixed time. 
How Linatab 5 works 
Linatab 5 is an antidiabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and postmeal sugar levels. 
quick tips 
Quick Tips 
Linatab 5 should be taken at the same time every day since this helps you remember to take it. 
It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety. 
Be careful while driving or operating machinery until you know how Linatab 5 affects you. 
Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting. 
description 
Brief Description 
Indication 
Type 2 Diabetes Mellitus 
Administration 
May administer with or without food 
Adult Dose 
Oral Type 2 diabetes mellitus Adult: 5 mg once daily. Indicated for adults with diabetes mellitus type II along with diet and exercise to lower blood sugar; may be used as monotherapy or in combination with other common antidiabetic medications including metformin, sulfonylurea, pioglitazone, or insulin. Elderly: No dose adjustment is necessary based on age. Hepatic or renal impairment: No dosage adjustment required. 
Child Dose 
Safety and efficacy not established 
Renal Dose 
Renal Impairment: No dose adjustment. 
Contraindication 
Patients with a history of a hypersensitivity reaction to linagliptin, such as urticaria, angioedema, or bronchial hyperreactivity. Type 1 DM. Treatment of diabetic ketoacidosis. 
Mode of Action 
Dipeptidyl peptidase 4 (DPP-4) inhibitor; increases and prolongs incretin hormone activity which is inactivated by DPP-4 enzyme. Incretins regulate glucose homeostasis by increasing insulin synthesis and release from pancreatic beta cells and reducing glucagon secretion from pancreatic alpha cells . 
Precaution 
Concomitant use w/ sulphonylureas which are known to cause hypoglycemia; dose reduction of sulphonylureas may be considered. May affect ability to drive or operate machinery. Childn. Elderly >75 yr. Pregnancy & lactation. Lactation: Unknown whether distributed in breast milk; caution advised 
Side Effect 
1-10% Nasopharyngitis (4.3%),Hyperlipidemia (2.8%; with pioglitazone),Cough (2.4%; with metformin and sulfonylurea),Hypertriglyceridemia (2.4%; with sulfonylurea),Weight gain (2.3%; with pioglitazone), Hypoglycemia 7.6% overall incidence, 22.9% incidence compared with placebo plus metformin and a sulfonylurea Incidence similar to placebo with monotherapy or combined with metformin or pioglitazone 
Interaction 
Increased risk of hypoglycaemia when used w/ an insulin secretagogue (e.g. sulfonylurea) or insulin. Plasma concentration of linagliptin may be decreased by strong inducers of P-glycoprotein (e.g. rifampicin) and may be increased by strong P-glycoprotein inhibitors (e.g. ritonavir).