UNSAFE 
Bislol 2.5 may cause excessive drowsiness with alcohol. 
Pregnancy 
Pregnancy 
CONSULT YOUR DOCTOR 
Information regarding the use of Bislol 2.5 during pregnancy is not available. Please consult your doctor. 
Breastfeeding 
Breastfeeding 
CONSULT YOUR DOCTOR 
Bislol 2.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. 
Driving 
Driving 
UNSAFE 
Bislol 2.5 may cause side effects which could affect your ability to drive. 
Kidney 
Kidney 
CAUTION 
Bislol 2.5 should be used with caution in patients with kidney disease. Dose adjustment of Bislol 2.5 may be needed. Please consult your doctor. Regular blood pressure monitoring is advisable for dose adjustment. 
Liver 
Liver 
CAUTION 
Bislol 2.5 should be used with caution in patients with liver disease. Dose adjustment of Bislol 2.5 may be needed. Please consult your doctor. Bislol 2.5 is started at a lower dose in these patients and further increased slowly with careful monitoring. 
description 
Medical Overview 
Introduction 
Bislol 2.5 belongs to a group of medicines called beta-blockers. It is used to treat high blood pressure (hypertension), angina (heart-related chest pain), irregular heart rhythms (arrhythmia). It also helps to prevent future heart attacks and stroke and to prevent migraine. Bislol 2.5 is also used to relieve the symptoms caused by an overactive thyroid gland. It may be prescribed alone or together with other medications. The dose and frequency depend on what you are taking it for and the severity of your condition. It may be taken empty stomach or with a meal, but take it regularly at the same time each day to get the most benefit. It may take several weeks before you get the full benefit of this medicine and you may need to take it for the rest of your life. However, it is important to continue taking it even if you feel well. Most people with high blood pressure do not feel ill and if you stop taking it, your condition may worsen. The main side effects of this medicine are fatigue, headache, slow heart rate, feeling dizzy, and nausea. These are usually mild and short-lived. It may also cause shortness of breath or low blood pressure in some people. To reduce the risk of side effects your doctor will probably start the medicine at a low dose and gradually increase it. Consult your doctor if the side effects bother you or do not go away. Before taking it, let your doctor know if you have any liver problems. It may also not be suitable for people who have a slow heart rate, severe circulation problems, severe heart failure, or low blood pressure. Pregnant or breastfeeding mothers should also consult their doctor before taking it. You must talk to your doctor to find out whether this medicine is suitable for you to use. You should have your blood pressure checked regularly to make sure that this medicine is working properly. Avoid drinking alcohol as it may increase certain side effects. 
Uses of Bislol 2.5 
Hypertension (high blood pressure) 
Angina (heart-related chest pain) 
Heart failure 
Side effects of Bislol 2.5 
Common 
Nausea 
Headache 
Fatigue 
Constipation 
Diarrhea 
Dizziness 
Cold extremities 
How to use Bislol 2.5 
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bislol 2.5 may be taken with or without food, but it is better to take it at a fixed time. 
How Bislol 2.5 works 
Bislol 2.5 is a beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body. 
quick tips 
Quick Tips 
It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position. 
It can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly. 
Do not stop taking Bislol 2.5 suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke. 
description 
Brief Description 
Indication 
Hypertension, Angina pectoris, Congestive heart failure 
Administration 
May be taken with or without food. 
Adult Dose 
The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily. For heart failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then 7.5 mg once daily for 4 weeks, then 10 mg once daily; max. 10 mg daily. Hepatic impairment: Severe: Initially, 2.5 mg/day. Max: 10 mg/day. Elderly: Hypertension 2.5-20 mg PO qDay Heart Failure 1.25 mg PO qDay; not to exceed 10 mg/day 
Renal Dose 
Renal impairment: CrCl (ml/min) <40 Initial: 2.5 mg/day. 
Contraindication 
Patients with cardiogenic shock, overt cardiac failure, second or third degree AV block and marked sinus bradycardia. 
Mode of Action 
Bisoprolol selectively and competitively blocks beta1-receptors but has little or no effect on beta2-receptors except at high doses. 
Precaution 
Impaired Renal or Hepatic Function. Lactation: excretion in milk unknown; use caution 
Side Effect 
1-10% Dizziness (10%),Dyssomnia (8%-10%),Bradyarrhythmia (9%),Upper respiratory infection (5%),Diarrhea (4%),Rhinitis (4%),Arthralgia (3%),Cough (3%),Dyspnea (2%),Nausea (2%),Pharyngitis (2%),Sinusitis (2%),Vomiting (2%) <1% Cold extremities,Hypotension,Depression,Dyspepsia,Bronchospasm Frequency Not Defined Aggravate CHF,Decrease HDL,Hypertriglyceridemia,Mask symptoms of hypoglycemia,Decreased exercise tolerance,Raynaud's phenomenon,May increase triglyceride levels and insulin resistance 
Pregnancy Category Note 
Pregnancy Category: C Lactation: excretion in milk unknown; use caution 
Interaction 
May potentiate AV conduction time and may increase negative inotropic effect w/ class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive sympathetic activity. May exacerbate rebound HTN upon discontinuance of clonidine treatment. Increased risk of bradycardia w/ digitalis glycosides. Reduced hypotensive effect w/ NSAIDs.